Cefamandole               package:nlme               R Documentation

Pharmacokinetics of Cefamandole

Description:

     The 'Cefamandole' data frame has 84 rows and 3 columns.

Format:

     This data frame contains the following columns:

     Subject a factor giving the subject from which the sample was
          drawn.

     Time a numeric vector giving the time at which the sample was
          drawn (minutes post-injection).

     conc a numeric vector giving the observed plasma concentration of
          cefamandole (mcg/ml).

Details:

     Davidian and Giltinan (1995, 1.1, p. 2) describe data obtained
     during a pilot study to investigate the pharmacokinetics of the
     drug cefamandole. Plasma concentrations of the drug were measured
     on six healthy volunteers at 14 time points following an
     intraveneous dose of 15 mg/kg body weight of cefamandole.

Source:

     Pinheiro, J. C. and Bates, D. M. (2000), _Mixed-Effects Models in
     S and S-PLUS_, Springer, New York.  (Appendix A.4)

     Davidian, M. and Giltinan, D. M. (1995), _Nonlinear Models for
     Repeated Measurement Data_,  Chapman and Hall, London.

Examples:

     data(Cefamandole)
     plot(Cefamandole)
     fm1 <- nlsList(SSbiexp, data = Cefamandole)
     summary(fm1)

