\HeaderA{mgus}{Monoclonal gammapothy data}{mgus}
\aliasA{mgus1}{mgus}{mgus1}
\aliasA{mgus2}{mgus}{mgus2}
\keyword{datasets}{mgus}
\keyword{survival}{mgus}
\begin{Description}\relax
Natural history of 241 subjects with monoclonal gammapothy of
undetermined significance (MGUS).
\end{Description}
\begin{Usage}
\begin{verbatim}
mgus
mgus1
mgus2
\end{verbatim}
\end{Usage}
\begin{Format}\relax
mgus: A data frame with 241 observations on the following 12 variables.
\Tabular{ll}{
id:& subject id \\
age:& age in years \\
sex:& \code{male} or \code{female} \\
dxyr:& year of diagnosis \\
pcdx:& for subjects who progress to a plasma cell malignancy \\
& the subtype of malignancy: multiple myeloma (MM) is the \\
& most common, followed by amyloidosis (AM), macroglobulinemia (MA),\\
& and other lymphprolifative (LP) \\
pctime:& days from MGUS until diagnosis of a plasma cell malignancy \\
futime:& days from diagnosis to last follow-up \\
death:& 1= follow-up is until death \\
alb:& albumin level at MGUS diagnosis \\
creat:& creatinine at MGUS diagnosis \\
hgb:& hemoglobin at MGUS diagnosis \\
mspike:& size of the monoclonal protien spike at diagnosis \\
}

mgus1: The same data set in start,stop format. Contains the id, age, sex, and
laboratory variable described above along with
\Tabular{ll}{ 
start, stop:& sequential intervals of time for each
subject \\
status:& =1 if the interval ends in an event \\
event:& the event type \\
}

mgus2: The mgus data, but formatted in the competing risks style.  Each
subject has three observations, one for time to death, one for time to
MM, and one for time to a PC malignancy other than MM.
Contains the id, age, sex, and
laboratory variable described above along with 
\Tabular{ll}{
time:& time to event or censoring \\
status:& 1 if the event occured, 0 otherwise \\
event:& death, myeloma, or other \\
}
\end{Format}
\begin{Details}\relax
Plasma cells are responsible for manufacturing immunoglobulins, an
important part of the immune defense. At any given time there are
estimated to be about \eqn{10^6}{} different immunoglobulins in the circulation
at any one time.  When a patient has a plasma cell malignancy the
distribuion will become dominated by a single isotype, the product of
the malignant clone, visible as a spike on a serum protein
electrophoresis. Monoclonal gammapothy of undertermined significance
(MGUS) is the presence of such a spike, but in a patient with no
evidence of overt malignancy.  This data set of 241 sequential subjects
at Mayo Clinic was the groundbreaking study defining the natural history
of such subjects.
\end{Details}
\begin{Source}\relax
Mayo Clinic data courtesy of Dr. Robert Kyle.
\end{Source}
\begin{References}\relax
R Kyle, Benign monoclonal gammopathy -- after 20 to 35 years of
follow-up,
Mayo Clinic Proc 1993; 68:26-36.
\end{References}

