mgus                package:survival                R Documentation

_M_o_n_o_c_l_o_n_a_l _g_a_m_m_a_p_o_t_h_y _d_a_t_a

_D_e_s_c_r_i_p_t_i_o_n:

     Natural history of 241 subjects with monoclonal gammapothy of
     undetermined significance (MGUS).

_U_s_a_g_e:

     mgus
     mgus1
     mgus2

_F_o_r_m_a_t:

     mgus: A data frame with 241 observations on the following 12
     variables.

       id:      subject id
       age:     age in years
       sex:     'male' or 'female'
       dxyr:    year of diagnosis
       pcdx:    for subjects who progress to a plasma cell malignancy
                the subtype of malignancy: multiple myeloma (MM) is the
                most common, followed by amyloidosis (AM), macroglobulinemia (MA),
                and other lymphprolifative (LP)
       pctime:  days from MGUS until diagnosis of a plasma cell malignancy
       futime:  days from diagnosis to last follow-up
       death:   1= follow-up is until death
       alb:     albumin level at MGUS diagnosis
       creat:   creatinine at MGUS diagnosis
       hgb:     hemoglobin at MGUS diagnosis
       mspike:  size of the monoclonal protien spike at diagnosis

     mgus1: The same data set in start,stop format. Contains the id,
     age, sex, and laboratory variable described above along with

       start, stop:  sequential intervals of time for each subject
       status:       =1 if the interval ends in an event
       event:        the event type

     mgus2: The mgus data, but formatted in the competing risks style. 
     Each subject has three observations, one for time to death, one
     for time to MM, and one for time to a PC malignancy other than MM.
     Contains the id, age, sex, and laboratory variable described above
     along with 

       time:    time to event or censoring
       status:  1 if the event occured, 0 otherwise
       event:   death, myeloma, or other

_D_e_t_a_i_l_s:

     Plasma cells are responsible for manufacturing immunoglobulins, an
     important part of the immune defense. At any given time there are
     estimated to be about 10^6 different immunoglobulins in the
     circulation at any one time.  When a patient has a plasma cell
     malignancy the distribuion will become dominated by a single
     isotype, the product of the malignant clone, visible as a spike on
     a serum protein electrophoresis. Monoclonal gammapothy of
     undertermined significance (MGUS) is the presence of such a spike,
     but in a patient with no evidence of overt malignancy.  This data
     set of 241 sequential subjects at Mayo Clinic was the
     groundbreaking study defining the natural history of such
     subjects.

_S_o_u_r_c_e:

     Mayo Clinic data courtesy of Dr. Robert Kyle.

_R_e_f_e_r_e_n_c_e_s:

     R Kyle, Benign monoclonal gammopathy - after 20 to 35 years of
     follow-up, Mayo Clinic Proc 1993; 68:26-36.

