# SIGNATURE Applications
Keywords: EMBOSS, European Molecular Biology Open Source Software Suite, bioinformatics, EBI, European Bioinformatics Institute, Molecular Biology, Computational Biology, Open Source, Software, Database

The SIGNATURE programs were developed by Jon Ison and colleagues at MRC HGMP for their protein domain research. They are included as an EMBASSY package as a work in progress.

### Applications in the current signature release

Program name | Description
--- | ---
libgen | Generate discriminating elements from alignments
matgen3d | Generate a 3D-1D scoring matrix from CCF files
rocon | Generates a hits file from comparing two DHF files
rocplot | Performs ROC analysis on hits files
siggen | Generates a sparse protein signature from an alignment
siggenlig | Generates ligand-binding signatures from a CON file
sigscan | Generates hits (DHF file) from a signature search
sigscanlig | Searches ligand-signature library & writes hits (LHF file)