mantelhaen.test            package:stats            R Documentation

_C_o_c_h_r_a_n-_M_a_n_t_e_l-_H_a_e_n_s_z_e_l _C_h_i-_S_q_u_a_r_e_d _T_e_s_t _f_o_r _C_o_u_n_t _D_a_t_a

_D_e_s_c_r_i_p_t_i_o_n:

     Performs a Cochran-Mantel-Haenszel chi-squared test of the null
     that two nominal variables are conditionally independent in each
     stratum, assuming that there is no three-way interaction.

_U_s_a_g_e:

     mantelhaen.test(x, y = NULL, z = NULL,
                     alternative = c("two.sided", "less", "greater"),
                     correct = TRUE, exact = FALSE, conf.level = 0.95)

_A_r_g_u_m_e_n_t_s:

       x: either a 3-dimensional contingency table in array form where
          each dimension is at least 2 and the last dimension
          corresponds to the strata, or a factor object with at least 2
          levels.

       y: a factor object with at least 2 levels; ignored if 'x' is an
          array.

       z: a factor object with at least 2 levels identifying to which
          stratum the corresponding elements in 'x' and 'y' belong;
          ignored if 'x' is an array.

alternative: indicates the alternative hypothesis and must be one of
          '"two.sided"', '"greater"' or '"less"'. You can specify just
          the initial letter. Only used in the 2 by 2 by K case.

 correct: a logical indicating whether to apply continuity correction
          when computing the test statistic. Only used in the 2 by 2 by
          K case.

   exact: a logical indicating whether the Mantel-Haenszel test or the
          exact conditional test (given the strata margins) should be
          computed. Only used in the 2 by 2 by K case.

conf.level: confidence level for the returned confidence interval. Only
          used in the 2 by 2 by K case.

_D_e_t_a_i_l_s:

     If 'x' is an array, each dimension must be at least 2, and the
     entries should be nonnegative integers.  'NA''s are not allowed. 
     Otherwise, 'x', 'y' and 'z' must have the same length.  Triples
     containing 'NA''s are removed.  All variables must take at least
     two different values.

_V_a_l_u_e:

     A list with class '"htest"' containing the following components: 

statistic: Only present if no exact test is performed.  In the
          classical case of a 2 by 2 by K table (i.e., of dichotomous
          underlying variables), the Mantel-Haenszel chi-squared
          statistic; otherwise, the generalized Cochran-Mantel-Haenszel
          statistic.

parameter: the degrees of freedom of the approximate chi-squared
          distribution of the test statistic (1 in the classical case).
          Only present if no exact test is performed.

 p.value: the p-value of the test.

conf.int: a confidence interval for the common odds ratio. Only present
          in the 2 by 2 by K case.

estimate: an estimate of the common odds ratio.  If an exact test is
          performed, the conditional Maximum Likelihood Estimate is
          given; otherwise, the Mantel-Haenszel estimate. Only present
          in the 2 by 2 by K case.

null.value: the common odds ratio under the null of independence, '1'.
          Only present in the 2 by 2 by K case.

alternative: a character string describing the alternative hypothesis.
          Only present in the 2 by 2 by K case.

  method: a character string indicating the method employed, and
          whether or not continuity correction was used.

data.name: a character string giving the names of the data.

_N_o_t_e:

     The asymptotic distribution is only valid if there is no three-way
     interaction.  In the classical 2 by 2 by K case, this is
     equivalent to the conditional odds ratios in each stratum being
     identical.  Currently, no inference on homogeneity of the odds
     ratios is performed.

     See also the example below.

_R_e_f_e_r_e_n_c_e_s:

     Alan Agresti (1990). _Categorical data analysis_. New York: Wiley.
     Pages 230-235.

_E_x_a_m_p_l_e_s:

     ## Agresti (1990), pages 231--237, Penicillin and Rabbits
     ## Investigation of the effectiveness of immediately injected or 1.5
     ##  hours delayed penicillin in protecting rabbits against a lethal
     ##  injection with beta-hemolytic streptococci.
     Rabbits <-
     array(c(0, 0, 6, 5,
             3, 0, 3, 6,
             6, 2, 0, 4,
             5, 1, 6, 0,
             2, 5, 0, 0),
           dim = c(2, 2, 5),
           dimnames = list(
               Delay = c("None", "1.5h"),
               Response = c("Cured", "Died"),
               Penicillin.Level = c("1/8", "1/4", "1/2", "1", "4")))
     Rabbits
     ## Classical Mantel-Haenszel test
     mantelhaen.test(Rabbits)
     ## => p = 0.047, some evidence for higher cure rate of immediate
     ##               injection
     ## Exact conditional test
     mantelhaen.test(Rabbits, exact = TRUE)
     ## => p - 0.040
     ## Exact conditional test for one-sided alternative of a higher
     ## cure rate for immediate injection
     mantelhaen.test(Rabbits, exact = TRUE, alternative = "greater")
     ## => p = 0.020

     ## UC Berkeley Student Admissions
     mantelhaen.test(UCBAdmissions)
     ## No evidence for association between admission and gender
     ## when adjusted for department.  However,
     apply(UCBAdmissions, 3, function(x) (x[1,1]*x[2,2])/(x[1,2]*x[2,1]))
     ## This suggests that the assumption of homogeneous (conditional)
     ## odds ratios may be violated.  The traditional approach would be
     ## using the Woolf test for interaction:
     woolf <- function(x) {
       x <- x + 1 / 2
       k <- dim(x)[3]
       or <- apply(x, 3, function(x) (x[1,1]*x[2,2])/(x[1,2]*x[2,1]))
       w <-  apply(x, 3, function(x) 1 / sum(1 / x))
       1 - pchisq(sum(w * (log(or) - weighted.mean(log(or), w)) ^ 2), k - 1)
     }
     woolf(UCBAdmissions)
     ## => p = 0.003, indicating that there is significant heterogeneity.
     ## (And hence the Mantel-Haenszel test cannot be used.)

