\HeaderA{Phenobarb}{Phenobarbitol Kinetics}{Phenobarb}
\keyword{datasets}{Phenobarb}
\begin{Description}\relax
The \code{Phenobarb} data frame has 744 rows and 7 columns.
\end{Description}
\begin{Format}\relax
This data frame contains the following columns:
\describe{
\item[Subject] an ordered factor identifying the infant.

\item[Wt] a numeric vector giving the birth weight of the infant (kg).

\item[Apgar] an ordered factor giving the the 5-minute Apgar score for
the infant.  This is an indication of health of the newborn
infant.

\item[ApgarInd] a factor indicating whether the 5-minute Apgar score is \code{< 5}
or \code{>= 5}. 

\item[time] a numeric vector giving the time when the sample is drawn or
drug administered (hr).

\item[dose] a numeric vector giving the dose of drug administered
(\eqn{u}{\mu}g/kg).

\item[conc] a numeric vector giving the phenobarbital concentration in
the serum (\eqn{u}{\mu}g/L).

}
\end{Format}
\begin{Details}\relax
Data from a pharmacokinetics study of phenobarbital in neonatal
infants.  During the first few days of life the infants receive
multiple doses of phenobarbital for prevention of seizures.  At
irregular intervals blood samples are drawn and serum phenobarbital
concentrations are determined.  The data
were originally given in Grasela and Donn(1985) and are analyzed
in Boeckmann, Sheiner and Beal (1994), in
Davidian and Giltinan (1995), and in Littell et al. (1996).
\end{Details}
\begin{Source}\relax
Pinheiro, J. C. and Bates, D. M. (2000), \emph{Mixed-Effects Models in S
and S-PLUS}, Springer, New York.  (Appendix A.23)

Davidian, M. and Giltinan, D. M. (1995), \emph{Nonlinear Models for
Repeated Measurement Data},  Chapman and Hall, London.  (section 6.6)

Grasela and Donn (1985), Neonatal population pharmacokinetics of
phenobarbital derived from routine clinical data,
\emph{Developmental Pharmacology and Therapeutics}, \bold{8},
374-383.

Boeckmann, A. J., Sheiner, L. B., and Beal, S. L. (1994),
\emph{NONMEM Users Guide: Part V}, University of California, San
Francisco.

Littell, R. C., Milliken, G. A., Stroup, W. W. and Wolfinger,
R. D. (1996), \emph{SAS System for Mixed Models}, SAS Institute,
Cary, NC.
\end{Source}

